Phosphodiesterase type-5 (PDE-5) inhibitors are medicines that are used to block the degradation of cGMP (Cyclic guanosine monophosphate) in smooth muscle cells that supply the central erectile tissues of the penis. These inhibitors provoke the relaxation of smooth muscles and sustain healthy penile function. Physicians usually prescribe PDE-5 inhibitors such as Levitra (Vardenafil), Viagra (Sildenafil Citrate), or Cialis (Tadalafil) to treat erectile function problems or Erectile Dysfunction (ED). These inhibitors may also treat other sexual dysfunctions such as Premature Ejaculation (PE) in men.
PDE-5 enzymes are present in many parts of the body such as the smooth muscle of the corpus cavernosum, skeletal muscle, cerebral and pancreatic tissues, vascular and visceral smooth muscle, platelets, lungs, and kidneys.
Can Phosphodiesterase type-5 inhibitors cure Erectile Dysfunction?
These medicines provoke vasodilatation in the genital region and block the breakdown of cGMP substance and the prolonged action of Nitric Oxide (NO). The erectile function is dependent on the NO release, which triggers cGMP production. Alongside sexual stimulation, NO is released from the nerve endings in the corpus cavernosum.
Commonly, PDE-5 medicines cannot cure ED. There are other methods to cure erectile function problems such as injections or surgery.
When Doctors prescribe PDE-5 Inhibitors?
Usually, physicians prescribe these medicines to treat certain men’s health problems including benign prostatic hyperplasia (BPH), pulmonary artery disease (PAH), and erectile dysfunction.
- Erectile Dysfunction is one of the most common sexual disorders in men. In this condition, males lose the ability to get and maintain an erection. An ED may occur due to several factors such as mental or mood disorders, hypertension (high blood pressure), diabetes, and others.
- BPH is a health problem that appears in men usually after 50 years old. This is a condition when a rapid increase in prostatic stromal cells may lead to an enlarged prostate.
- PAH is hypertension of the arteries going to the lungs. A symptom of high blood pressure is when pulmonary arterial pressure exceeds 25 mm Hg.
In case you experience any of the conditions listed above, do not self-medicate. It is advised to see a doctor for a proper diagnosis and treatment.
Best PDE-5 Inhibitor
There are some PDE-5 medicines that are usually prescribed by physicians. For example:
- Sildenafil Citrate – A medicine that contains Sildenafil as an active ingredient is called Viagra. This medicine starts working between 30 minutes and 1 hour.
- Tadalafil – A medicine that contains Tadalafil as an active ingredient is Cialis. This medicine is one of the best options for the treatment of BPH and ED.
- Vardenafil – Levitra is the brand name that contains Vardenafil as an active ingredient. This ED drug should be taken 30-60 minutes before sexual activity. The duration of the effect ranges between 5-7 hours. Furthermore, it is recommended to avoid fatty and heavy meals while you administer the pill because it may lead to delayed effects.
Frequently Asked Questions
What fruit is a natural Sildenafil Citrate?
Watermelon is considered to be a natural Viagra. This fruit contains citrulline, an amino acid that helps to relax and widen blood vessels.
Is a PDE-5 medicine safe?
If these medicines are prescribed by a doctor, are safe for use. You may experience side effects while using PDE-5 medications if you have some pre-existing diseases (such as cardiovascular disease) or you administer more tablets than are allowed.
What are the common adverse effects of PDE-5 inhibitors?
In most cases side effects of these medicines are minor. For example headaches, flushing, and stomach discomfort. However, if you have pre-existing diseases or using an increased dose of these drugs, you may notice severe adverse effects. Examples include prolonged or painful erections, blurred vision, irregular heartbeats, and others. Discuss with a healthcare provider if you experience any of the adverse reactions listed above or any other effects.
