Avanafil vs Tadalafil

Both these medicines are used in the treatment of sexual dysfunctions, including Erectile Dysfunction (ED). ED is a sexual condition when a man cannot get and sustain an erection. Although Avanafil and Tadalafil work similarly, they have several differences. In this article, we will talk about the differences between Avanafil and Tadalafil.

Avanafil vs Tadalafil

You can find these medicines under the brand names Cialis (Tadalafil) and Stendra (Avanafil). Both these drugs belong to the class of medicines called phosphodiesterase type-5 (PDE-5) inhibitors. It works by improving blood flow to the penis tissues, helping you maintain a hard erection. However, these drugs have distinct characteristics while they are working similarly. For example differences in their active ingredients, time to begin working, the duration of the effect, price, potential adverse reactions, and others.

Active Ingredients

The active ingredient of Stendra is Avanafil. This active ingredient received FDA approval to treat ED in 2012. Cialis contains Tadalafil as an active ingredient. It received FDA approval to treat ED in 2003 and benign prostatic hyperplasia (BPH).

How long take to start working?

Avanafil works faster than Tadalafil. If you administer a 100 or 200 mg dose, you’ll see the effect within 15 minutes. Tadalafil takes longer to begin working but has an action onset between 30 minutes to 2 hours after using this medicine. However, Cialis remains effective in your body for roughly 36 hours. The effect of Avanafil may last up to 4-6 hours.


Avanafil comes usually in three strengths such as 50 mg, 100 mg, and 200 mg. Commonly, you should administer one of them 15 minutes before sexual activity. The starting dose often is 100 mg but may be adjusted to 50 mg due to side effects or increased to 200 if you do not notice the desired result. In any case, you should not administer more than one tablet daily because it may lead to an overdose. Symptoms of overdose include severe dizziness, fainting, trouble breathing, passing out, and others. Immediately contact a physician if you experience any of the symptoms listed above.

Tadalafil comes in several dosages such as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets. The starting Cialis dose is usually 10 mg and may be adjusted by your healthcare provider in case you experience side effects or do not notice the desired result. Lower doses of this medication can help you to treat ED as well as manage BPH.

Adverse Effects

Using ED medications may give you some adverse reactions. In any case, if your body adjusts to the active ingredient of these medicines, you may not experience any of the following negative effects. Check below some common adverse effects of Avanafil and Tadalafil:

  • Headaches
  • Nausea
  • Nasal congestion
  • Changes in vision
  • Feeling of warmth
  • Back pain

Rare Adverse Effects

This category of side effects may occur rarely usually due to an increased dose of medicine. If you experience any of the following adverse reactions, stop using ED medication and consult a doctor at once. For example:

Tadalafil remains in the body for a longer time and side effects may last longer as well. However, Avanafil is removed from the body earlier and adverse effects are fewer.


The price of Stendra is relatively high because it is the newest ED drug on the market. The price is about $400 for 6 tablets of 200 mg. However, there are several generic versions of Avanafil in our online pharmacy.

Furthermore, Cialis is also available in generic versions that are cheaper than brand-name medications. The average price for 30 tablets of generic Tadalafil is roughly $24.

Additionally, generic medicines contain the same active ingredient, effectiveness, and safety but are cheaper. These generic drugs are produced by various pharmaceutical companies after the patent of the brand names medicines.


If you wish for prolonged effects, you should choose Tadalafil. However, if you want quick results, you can choose Avanafil. It is not allowed to use any ED medicine without a physician’s approval because it may lead to unpleasant results. In addition, do not administer more tablets than are allowed because it may result in an overdose.

Frequently Asked Questions

Is Avanafil good?

This is an effective erectile dysfunction medication. Avanafil helps to improve the quality of erections and sexual performance.

Is it possible to administer Tadalafil and Avanafil together?

No, it is not allowed to administer any two ED medicines at the same time. As we know, PDE-5 inhibitors decrease blood pressure, and using both ED drugs may lead to extremely low blood pressure. Moreover, taking Tadalafil and Avanafil together, you may be at higher risk of side effects such as Priapism, flushing, fainting, dizziness, lightheadedness, heart palpitations, and others.

Which erectile dysfunction medicine is better Avanafil or Tadalafil?

The Tadalafil effect lasts longer than Avanafil. Therefore, the side effects also may last longer. However, if your body adjusts to the active ingredient, any of the side effects listed in this document may disappear. Additionally, your healthcare provider may be able to help you to prevent or avoid adverse reactions.

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