Tretiva 5 mg
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Tretiva 5 mg


Tretiva 5 mg is used in the treatment of nodular acne. It contains Isotretinoin as an active ingredient. Consult with your healthcare provider before using this medication.

30 caps $12.00
60 caps $21.00
90 caps $30.00

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This medicine is often used in patients who are suffering from severe cystic acne (nodular acne) that has not responded to other treatments. Tretiva 5 mg works by reducing facial oil (sebum) production. Doctors may also prescribe this medicine to treat other conditions not listed in this article. The active ingredient of this drug is Isotretinoin. Nevertheless, it also contains other inactive ingredients such as gelatin, glycerin, titanium dioxide, soybean oil, butylated hydroxyanisole, and others. Tretiva 5 mg belongs to a group of medicines called retinoids. This medication should not be used without the doctor’s approval because it may lead to unpleasant results.

The manufacturer of Tretiva 5 mg is Intas Pharmaceuticals Ltd.


The recommended dose per day is usually two capsules or as directed by your healthcare professional. Take the capsule whole by mouth with a glass full of water preferably on an empty stomach. Do not use other drinks such as alcohol because it may elevate your risk of adverse effects. While swallowing, do not crush, chew, or break the capsule. Otherwise, you may notice a bitter taste in your mouth. You can administer this pill with milk or light food if nausea or stomach upset occurs. To get the most benefit from this product, you should use it each day and at the same time.

Additionally, your condition will not improve faster if you decide to use it more frequently than is prescribed by a doctor. A physician may gradually increase the dosage for several weeks if you do not notice the desired result.

The liquid form of this medicine requires a special measuring spoon or cup. If you are using a household spoon, you may get the wrong dose, which may also increase your risk of adverse effects. If you see no improvements in your health condition after a few weeks, see your physician.


The dosages vary among patients because it depends on the severity of the condition, other drugs you may use, response to therapy, and age. In case you have doubts about what dosage is better for you, avoid using this product or discuss it with a doctor. In addition, it is not advised to interrupt the treatment suddenly without a physician’s recommendation because it may lead to a return of the symptoms. Hence, your condition may become difficult to treat.

Missed Dose

In some cases, you may forget to use this medicine and physicians advise taking the dose as soon as possible. Skip the missed dose and continue the normal schedule as prescribed, if it is near the time for the next dose. Do not administer an increased dose of Isotretinoin the next time to catch up because you may experience severe side effects.


Usually, an overdose may occur due to an increased dose of this medicine. Stop taking this medicine and ask for medical help right away, if any of the following symptoms occur. Examples include severe dizziness, trouble breathing, fainting, fast or pounding heartbeat, and others. If you have any questions, ask your healthcare provider.

Adverse Effects of Tretiva 5 mg

Tretiva 5 mg may give you some side effects during treatment. However, if your body adjusts to Isotretinoin, you may not experience any of the following adverse effects. Overdose, dehydration, and allergy are some factors that can provoke side effects.

Common Adverse Effects

Do not ignore the following adverse effects but tell your doctor if experience one or both of them at the same time. Check some examples below:

  • Dry skin, lips, or mouth
  • Minor swelling
  • Rash
  • Crusty skin
  • Stomach upset
  • Thinning of the hair

Severe Adverse Effects

You may rarely experience this category of adverse effects due to an increased dose of Isotretinoin. Stop using this product and consult a doctor right away if any of the following negative effects occur. Additionally, your doctor may help you to avoid or prevent side effects. Check below some examples:

  • Nosebleeds
  • Mental disorders (such as depression, anxiety, and others)
  • Back, joint, or muscle pain
  • Fever
  • Painful swallowing
  • Chest pain
  • Hearing loss
  • Vision changes
  • Yellowing of the skin or eyes
  • Severe diarrhea
  • Ringing in the ears

Consult a doctor if you are experiencing any of the adverse reactions listed above or any other effects.


Isotretinoin may interact with other medicines and increase the risk of adverse effects or decrease the effectiveness of Tretiva 5 mg. Tell your healthcare provider about all products that you are using before taking Tretiva 5 mg. For example prescription medicines, nonprescription medicines, herbal products, supplements, vitamins, and others. Check below some examples of drug interaction:

  • Prednisone
  • Phenytoin
  • Acitretin
  • Bexarotene
  • Minocycline
  • Tetracycline
  • Alcohol
  • Aminolevulinic acid
  • Apalutamide
  • Bexarotene
  • Doxycycline
  • Demeclocycline
  • Drospirenone
  • Efavirenz
  • Hydrocortisone
  • Ketoconazole
  • Lomitapide
  • Leflunomide
  • Levoketoconazole
  • Methylprednisolone
  • Methoxsalen
  • Methotrexate
  • Nevirapine
  • Norethindrone
  • Sarecycline
  • Somatropin
  • Tretinoin
  • Thioguanine
  • Vitamin A
  • Warfarin
  • Verteporfin

Tretiva 5 mg may also interact with certain medical conditions. For example:

  • Increased serum triglycerides
  • Psychiatric disorders
  • Osteoporosis (brittle bones)
  • Intracranial hypertension

Discuss with a healthcare professional before using Tretiva 5 mg because this document does not contain a complete list of disease and drug interactions. Moreover, you should not stop, start, or change the dosages without the doctor’s approval because it may lead to unpleasant results.


It is not advised to use this medicine if any of the following cases occur. Examples include:

  • Liver or kidney disease
  • Eating disorders (such as anorexia nervosa)
  • Alcohol abuse
  • Bone loss conditions (such as osteomalacia, reduced bone density, and others)
  • Obesity
  • Mental or mood changes (such as depression)
  • Diabetes
  • High blood fats (triglycerides)
  • Pancreatitis

Tretiva 5 mg may make you more sensitive to the sun. Avoid sunlamps, and tanning booths, and use sunscreen, and protective wear when outdoors. Inform your doctor right away, if you are sunburned or have skin redness and blisters.

Using this medicine during pregnancy is prohibited. In addition, breastfeeding also is not allowed because similar drugs pass into breast milk. For more details talk to a doctor.


  • You may find certain differences between this document and the doctor’s prescription. To treat your diseases fast and safely, it is advised to follow the physician’s recommendations only.
  • Do not use Tretiva 5 mg after its shelf life because it may increase your risk of severe side effects.

Additional information

Active Ingredient



Intas Pharmaceuticals Ltd.


10 caps/blister



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