How Valisone/Betnovate Ointment Works?
In the human body, the natural hormone cortisol, also called hydrocortisone, has multiple effects. Colloquially, the hormone is also called “cortisone”, but this is not correct because it is the inactivated (ineffective) form of cortisol.
Cortisol has the following functions in the body:
- It increases the production of blood sugar (glucose) in the liver, in order to be able to supply the body quickly with energy
- In stress situations.
- It accelerates the protein turnover – also the protein degradation supplies energy.
- It has a dampening effect on the immune system.
Valisone/Betnovate Ointment is a synthetic cortisol derivative. He is about 25 to 30 times stronger than his natural role model. All glucocorticoids are classified according to their potency in classes from 1 (weakly effective) to 4 (very strong effective) – Valisone/Betnovate Ointment is assigned here to the class 3 (strongly effective).
Compared to cortisol, Valisone/Betnovate Ointment is less quickly degraded or inactivated in the body because it can not be broken down by the body’s own enzymes to cortisone.
Degradation and excretion of Valisone/Betnovate Ointment
Valisone/Betnovate Ointment is quickly taken from the gastrointestinal tract after ingestion and reaches the highest blood levels after one to two hours. The biological half-life, ie the time in which the effect is reduced by half, is very long at 36 to 54 hours. For comparison, the half-life of cortisol is about ten hours.
The liver converts Valisone/Betnovate Ointment into a more soluble compound. This is then excreted via the bile with the stool.
When is Valisone/Betnovate Ointment used?
Valisone/Betnovate Ointment is locally applied to the skin in case of skin diseases such as psoriasis, atopic dermatitis, allergic or itchy skin reactions (hives). This Valisone/Betnovate Ointment, gel or cream are used, which contain the active ingredient as so-called esters: In these compounds, fatty acids are attached to the Valisone/Betnovate Ointment, in order to increase its absorption into the skin. Examples are:
- Fluid retention (with swelling) in the brain (cerebral edema)
- Initial treatment of severe skin diseases (see above)
- Rheumatoid arthritis
- Further severe inflammatory reactions in the body
However, it is always important that these are not bacterial infections, as the attenuation of the immune system by Valisone/Betnovate Ointment could make the infections particularly flare up.
The duration of the application is individually different.
Valisone/Betnovate Ointment Dosage?
The most widely used form of Valisone/Betnovate Ointment is the local treatment with betamethasone ointment for skin diseases. Due to the long duration of action, the ointment often only needs to be applied once a day.
In addition, often betamethasone tablets are still used, which must be taken after medical treatment plan. In general, the dose is initially increased rapidly, then kept constant (plateau phase) until the disease has subsided, and then slowly reduced to stop the therapy. The tablets are usually taken in the morning, as the body’s cortisol levels are highest in the morning after getting up.
What are the side effects of Valisone/Betnovate Ointment?
Side effects are primarily to be expected only in case of internal use (eg betamethasone tablets or injections). When applied topically to the skin, only a negligible amount of the drug enters the blood stream.
The side effects of Valisone/Betnovate Ointment are dose-related. At high dosages and / or long-term use, the following undesirable reactions are possible:
- increased blood lipid and cholesterol levels
- changes in electrolyte levels in the blood
- muscle weakness
- mood swings
- change in the number of specific blood cells
Many of these side effects can be effectively avoided by administering a dose as high as necessary but as low as possible.
What should be considered when taking Valisone/Betnovate Ointment?
Valisone/Betnovate Ointment is broken down in the body by certain enzymes (especially CYP3A4). The concomitant use of other medicinal products that stimulate these enzymes reduces the Valisone/Betnovate Ointment effect. Such drugs include the antibiotic rifampicin and the epilepsy agents phenytoin, carbamazepine and phenobarbital.
Conversely, concomitant administration of drugs that inhibit the enzymes in question can enhance Valisone/Betnovate Ointment activity. This applies, for example, to the antifungal agents ketoconazole and itraconazole).
In combination with ACE inhibitors (antihypertensives such as ramipril, enalapril, lisinopril) can lead to blood picture changes.
Valisone/Betnovate Ointment can reduce the hypoglycemic effect of oral antidiabetics.
Non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, indomethacin), which are often taken as a headache medication, in combination with Valisone/Betnovate Ointment can increasingly lead to gastrointestinal bleeding.
Glucocorticoids such as Valisone/Betnovate Ointment overcome the placental barrier and pass into breast milk, so they should not be used during pregnancy and lactation. Valisone/Betnovate Ointment is used in the medically-based delivery before the actual delivery date in order to stimulate the premature development of the lungs in the unborn child.
Where can I buy Valisone/Betnovate Ointment?
All medications containing Valisone/Betnovate Ointment are subject to medical prescription. However, you can buy Valisone/Betnovate Ointment without a prescription on our website.
Since when is Valisone/Betnovate Ointment known?
Already in 1855, the scientist Thomas Addison (after the Addison’s disease was named, in which there is a hypofunction of the cortisol-producing adrenal glands) described a disease that could be successfully treated with an adrenal extract. The hormone cortisol contained therein was identified in 1936 by the research groups of Kendall and Reichstein. In 1948, it was also possible to produce cortisol in the laboratory for the first time. This also offered the opportunity to change its structure to optimize the duration of action and reduce the side effect potential. This eventually led to the development of betamethasone.