Benoquin Hydroquinone Cream 20g tube 20%


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How Benoquin Hydroquinone Cream works?

Hydrochinones “depigment” the skin, making it less visible to pigmented pigment. There is less pigment produced. This is possible since the transformation of tyrosine to melanin is braked. That sounds pretty good, so I’ll try to explain it briefly:

Pigment or melanin is the brown dye produced by the skin. This melanin also ensures that the skin gets its brown color. When melanin is produced smoothly, you get a uniformly brown color. If this process is interfering with hormones, wounds or acne, pigment patches are created. Hydrochinones suppress the production of melanin. The skin does not have the ability to produce brown color and transport it to the places where the process is disturbed. It does not bleak the skin, but prevents the development of pigment spots (Zoe Draelos, Cosmeceuticals).

Hydroquinone cream has a bleaching effect and is therefore used in local hyperpigmentation of the skin. In comparative studies, hydroquinone is not effective in all patients. With a naturally pigmented skin there is a greater risk of the occurrence of (irreversible) side effects. Especially in the summer months, patients should avoid sunlight and use a broad spectrum (UVA and UVB) sunscreen. The therapeutic value of hydroquinone cream is insufficiently substantiated by current standards and is attributed to clinical experience that has not been systematically documented.

Benoquin Hydroquinone Cream is very effective

Hydroquinone cream is perhaps the most effective inhibitor of pigment cells. Nevertheless, results are visible only after a few weeks to months at the earliest. However, in most cases, pigment spots will never disappear 100% and an additional treatment with a chemical peel is certainly to be considered.

Incidentally, hydroquinone does not specifically work against the pigment in only pigmentation spots. All pigment cells in the skin are inhibited in the production of pigment. This means that not only pigment cells become lighter, the surrounding skin will also become brown less quickly.

Benoquin Hydroquinone Cream is not free of risks

Because hydroquinone cream never leaves pigmentation 100%, there is a risk of prolonged use, so that hydroquinone cream can lead to more pigmentation. There are various mechanisms that can play a role;

  • White spots may appear on the skin (leukoderma) due to direct damage of pigment cells by hydroquinone
    Hydroquinone can also directly irritate the skin causing it to become inflamed with PIH as a result. But here too, a direct effect of hydroquinone on pigment cells can lead to pigmentation spots.
  • Pigment serves as natural protection against UV. When the production is inhibited too much, UV can irritate the skin, causing it to become inflamed. This inflammation can again result in PIH. But UV can also directly irritate the pigment cells, causing pigmentation.
  • Change of the structure of pigment by a so-called photo-toxic reaction. This is a reaction in which the pigment, under the influence of UV, changes chemical structure. This creates a permanent blue / gray discoloration of the treated skin, which is therefore not treatable. This side effect is called ochronosis and usually only occurs after several years of continuous use of hydroquinone cream.
  • Animal experiments have shown that hydroquinone can cause cancer. This has not been demonstrated in humans to date and the future has to show whether there is also an increased risk for people.

How to prevent risks of Benoquin Hydroquinone Cream?

The risks of hyperpigmentation can generally be prevented by allowing use for a maximum of 6 months, after which a rest period of, for example, 2 months is inserted. In those two months, the original pigmentation spots can temporarily get worse again. A concentration of up to 5% is also desirable. Through the internet, hydroquinone is available illegally in concetrations that are sometimes much higher. With greater risks.

Personally, we prefer Brightenex and / or Brightalive from Zein Obagi in the treatment of pigmentation spots. These do not contain hydroquinone but various other ingredients that inhibit the pigment cells without bleaching the normal skin (as hydroquinone does). The risks of hydroquinone described above are therefore much smaller with Brightenex and / or Brightalive.

Temporarily we sometimes add hydroquinone cream to a regimen, often in combination with tretinoin cream, which increases the effectiveness of hydroquinone by improving the absorption of hydroquinone.

Benoquin Hydroquinone Cream Indications

Softening hyperpigmentation in melasma (pregnancy mask) and post-inflammatory hyperpigmentation.

Benoquin Hydroquinone Cream Dosage

Hyperpigmentation disorders, such as melasma:
Apply 1-2 times a day to the hyper pigmented skin areas. If no improvement occurs after up to 6 months, the therapy will stop. Hydroquinone should preferably not be used continuously for more than 2 years. When the intended depigmentation has been achieved, use the means only to maintain the depigmentation.

Use it carefully

  • Always protect yourself against the sun. Otherwise, we fight only the symptoms and not the cause. The sun “stimulates” melanin production, while hydroquinone brakes it.
  • Increase the application slowly. Start in three days. Is it good? Then use it every two days and then daily. Make sure your skin is not irritating. If so, be it less likely to use it.
  • Make it the best evening.
  • Do not expect immediate results. This will certainly take several weeks. Do not use unlimited hydrochinone, then terminate the application at least six months later.
  • In the Netherlands, products with hydroquinone are not freely available, unlike the USA ( RIVM ) and Germany, where it is available at low concentrations (0.5 to 2 percent). For higher concentrations (from 4 percent) you need a prescription from the GP or dermatologist. Keep up with the prescribed concentration that will be between two and four percent.

Benoquin Hydroquinone Cream Side effects

Skin irritation (burning or irritating sensation, itching, redness, dry skin). Sensitization, local hypopigmentation (leukoderma, confetti, vitiligo) and paradoxical hyperpigmentation (exogenous ochronosis) can also occur.

Reported adverse reactions Lareb
Report form side effects


There is insufficient data on the use during pregnancy in humans to assess the possible harmfulness.

Benoquin Hydroquinone Cream Contraindications

Lentigo maligna, melanoma, vitiligo.

Benoquin Hydroquinone Cream Warnings and precautions

The skin should be protected from sunlight (especially in the summer months) (sunlight reduces the depigmenting effect of hydroquinone). Avoid contact with the eyes, mouth, nasal mucosa and wounds (due to irritation). To prevent further dehydration of dry skin, the cream can be prepared with 25% glycerol instead of ethanol. Especially with naturally pigmented skin there is a risk of disfiguring confetti-like depigmentation and (sometimes irreversible) rebound hyperpigmentation (especially with long-term use of the 5% cream).

Benoquin Hydroquinone Cream Overdose

Single oral intake of 5-12 g hydroquinone causes symptoms such as intoxication with phenol; tremors, seizures and rarely severe haemolytic anemia may occur.

Benoquin Hydroquinone Cream Properties

The effect of hydroquinone is based on the inhibition of melanin synthesis in the melanocyte. The hyper pigmented skin whitens faster than normal skin. Rarely, complete reduction of hyperpigmentation occurs. After a few weeks a bleaching effect can already occur, but usually an effect is only achieved after 1-4 months. Depigmentation usually lasts 2-6 months after termination of therapy. Locally applied tretinoin strengthens the effect of hydroquinone cream. Combinations of hydroquinone 2% or 5% with tretinoin 0.05% are available as FNA preparation the cream is then prepared with lanette cream II.


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